/* PharmXD - Pharmacogenomic Dosing Advisor
   Mobile-first responsive design */

/* CSS Variables */
:root {
    --primary: #2563eb;
    --primary-dark: #1d4ed8;
    --primary-light: #dbeafe;
    --success: #16a34a;
    --success-light: #dcfce7;
    --warning: #ca8a04;
    --warning-light: #fef9c3;
    --danger: #dc2626;
    --danger-light: #fee2e2;
    --gray-50: #f9fafb;
    --gray-100: #f3f4f6;
    --gray-200: #e5e7eb;
    --gray-300: #d1d5db;
    --gray-400: #9ca3af;
    --gray-500: #6b7280;
    --gray-600: #4b5563;
    --gray-700: #374151;
    --gray-800: #1f2937;
    --gray-900: #111827;
    --radius: 12px;
    --radius-sm: 8px;
    --shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
    --shadow-lg: 0 10px 15px -3px rgba(0, 0, 0, 0.1), 0 4px 6px -2px rgba(0, 0, 0, 0.05);
}

/* Reset & Base */
*, *::before, *::after {
    box-sizing: border-box;
    margin: 0;
    padding: 0;
}

html {
    font-size: 16px;
    -webkit-text-size-adjust: 100%;
}

body {
    font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, sans-serif;
    line-height: 1.6;
    color: var(--gray-800);
    background: linear-gradient(135deg, var(--primary-light) 0%, var(--gray-100) 100%);
    min-height: 100vh;
}

/* App Container */
.app-container {
    max-width: 600px;
    margin: 0 auto;
    min-height: 100vh;
    display: flex;
    flex-direction: column;
    background: white;
    box-shadow: var(--shadow-lg);
}

/* Header */
.app-header {
    background: var(--primary);
    color: white;
    padding: 1.5rem 1rem;
    text-align: center;
}

.header-top {
    display: flex;
    align-items: center;
    justify-content: center;
    position: relative;
    margin-bottom: 0.25rem;
}

.lang-toggle {
    position: absolute;
    right: 0;
    top: 50%;
    transform: translateY(-50%);
    background: rgba(255, 255, 255, 0.2);
    border: 1px solid rgba(255, 255, 255, 0.3);
    border-radius: 20px;
    padding: 0.35rem 0.75rem;
    color: white;
    font-size: 0.8125rem;
    font-weight: 600;
    cursor: pointer;
    display: flex;
    align-items: center;
    gap: 0.35rem;
    transition: all 0.2s ease;
}

.lang-toggle:hover {
    background: rgba(255, 255, 255, 0.3);
}

.lang-toggle:active {
    transform: translateY(-50%) scale(0.95);
}

.lang-flag {
    font-size: 1rem;
}

.lang-code {
    letter-spacing: 0.5px;
}

.logo {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 0.5rem;
}

.logo-icon {
    font-size: 2rem;
}

.logo-text {
    font-size: 1.75rem;
    font-weight: 700;
    letter-spacing: -0.5px;
}

.tagline {
    font-size: 1rem;
    font-weight: 500;
    opacity: 1;
    margin-bottom: 0.5rem;
}

.tagline-sub {
    font-size: 0.8125rem;
    opacity: 0.85;
    max-width: 320px;
    margin: 0 auto;
    line-height: 1.4;
}

/* Main Content */
.app-main {
    flex: 1;
    padding: 1rem;
}

/* Steps */
.step {
    display: none;
    animation: fadeIn 0.3s ease;
}

.step.active {
    display: block;
}

@keyframes fadeIn {
    from { opacity: 0; transform: translateY(10px); }
    to { opacity: 1; transform: translateY(0); }
}

.step-header {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    margin-bottom: 1rem;
}

.step-number {
    width: 32px;
    height: 32px;
    background: var(--primary);
    color: white;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: 600;
    font-size: 0.875rem;
}

.step-header h2 {
    font-size: 1.25rem;
    font-weight: 600;
    color: var(--gray-800);
}

.step-content {
    background: var(--gray-50);
    border-radius: var(--radius);
    padding: 1.25rem;
}

.step-description {
    color: var(--gray-600);
    font-size: 0.9375rem;
    margin-bottom: 1.25rem;
}

/* Upload Zone */
.upload-zone {
    border: 2px dashed var(--gray-300);
    border-radius: var(--radius);
    padding: 2rem 1rem;
    text-align: center;
    background: white;
    transition: all 0.2s ease;
    cursor: pointer;
}

.upload-zone:hover,
.upload-zone.dragover {
    border-color: var(--primary);
    background: var(--primary-light);
}

.upload-icon {
    font-size: 3rem;
    margin-bottom: 0.75rem;
}

.upload-text {
    font-weight: 500;
    color: var(--gray-700);
    margin-bottom: 0.5rem;
}

.upload-or {
    color: var(--gray-400);
    font-size: 0.875rem;
    margin-bottom: 0.75rem;
}

.upload-button {
    display: inline-block;
    background: var(--primary);
    color: white;
    padding: 0.75rem 1.5rem;
    border-radius: var(--radius-sm);
    font-weight: 500;
    cursor: pointer;
    transition: background 0.2s ease;
}

.upload-button:hover {
    background: var(--primary-dark);
}

.upload-hint {
    font-size: 0.8125rem;
    color: var(--gray-400);
    margin-top: 0.75rem;
}

/* Demo Section */
.demo-section {
    margin-top: 1.5rem;
    padding-top: 1.5rem;
    border-top: 1px solid var(--gray-200);
    text-align: center;
}

.demo-section p {
    color: var(--gray-500);
    font-size: 0.875rem;
    margin-bottom: 0.75rem;
}

.demo-buttons {
    display: flex;
    gap: 0.75rem;
    justify-content: center;
}

.demo-btn {
    background: white;
    border: 1px solid var(--gray-300);
    border-radius: var(--radius-sm);
    padding: 0.75rem 1rem;
    cursor: pointer;
    transition: all 0.2s ease;
    text-align: left;
}

.demo-btn:hover {
    border-color: var(--primary);
    box-shadow: var(--shadow);
}

.demo-name {
    display: block;
    font-weight: 600;
    color: var(--gray-800);
}

.demo-desc {
    display: block;
    font-size: 0.75rem;
    color: var(--gray-500);
    margin-top: 0.125rem;
}

/* Loading Spinner */
.loading {
    text-align: center;
    padding: 2rem;
}

.spinner {
    width: 40px;
    height: 40px;
    border: 3px solid var(--gray-200);
    border-top-color: var(--primary);
    border-radius: 50%;
    animation: spin 1s linear infinite;
    margin: 0 auto 1rem;
}

@keyframes spin {
    to { transform: rotate(360deg); }
}

/* Profile Results */
.profile-summary {
    background: var(--primary-light);
    padding: 1rem;
    border-radius: var(--radius-sm);
    margin-bottom: 1rem;
    text-align: center;
}

.profile-summary p {
    color: var(--primary-dark);
}

.profile-summary strong {
    font-size: 1.25rem;
}

/* Gene Cards */
.gene-cards {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.gene-card {
    background: white;
    border-radius: var(--radius-sm);
    padding: 1rem;
    box-shadow: var(--shadow);
    border-left: 4px solid var(--gray-300);
}

.gene-card.normal {
    border-left-color: var(--success);
}

.gene-card.intermediate {
    border-left-color: var(--warning);
}

.gene-card.poor, .gene-card.ultrarapid {
    border-left-color: var(--danger);
}

.gene-card-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: 0.5rem;
}

.gene-name {
    font-weight: 600;
    color: var(--gray-800);
}

.gene-diplotype {
    font-size: 0.8125rem;
    color: var(--gray-500);
    font-family: monospace;
}

.gene-phenotype {
    font-size: 0.9375rem;
}

.phenotype-badge {
    display: inline-block;
    padding: 0.25rem 0.5rem;
    border-radius: 4px;
    font-size: 0.8125rem;
    font-weight: 500;
}

.phenotype-badge.normal {
    background: var(--success-light);
    color: var(--success);
}

.phenotype-badge.intermediate {
    background: var(--warning-light);
    color: var(--warning);
}

.phenotype-badge.poor, .phenotype-badge.ultrarapid {
    background: var(--danger-light);
    color: var(--danger);
}

/* Summary Card */
.summary-card {
    background: white;
    border-radius: var(--radius);
    padding: 1.25rem;
    box-shadow: var(--shadow);
    border: 1px solid var(--gray-200);
}

.summary-intro {
    text-align: center;
    color: var(--gray-600);
    margin-bottom: 1.25rem;
    font-size: 0.9375rem;
}

.summary-stats {
    display: flex;
    gap: 0.75rem;
    justify-content: center;
    margin-bottom: 1rem;
}

.summary-stat {
    flex: 1;
    max-width: 120px;
    text-align: center;
    padding: 1rem 0.5rem;
    border-radius: var(--radius-sm);
    border: 2px solid;
}

.summary-stat.standard {
    background: var(--success-light);
    border-color: var(--success);
}

.summary-stat.caution {
    background: var(--warning-light);
    border-color: var(--warning);
}

.summary-stat.avoid {
    background: var(--danger-light);
    border-color: var(--danger);
}

.stat-icon {
    display: block;
    font-size: 1.5rem;
    margin-bottom: 0.25rem;
}

.summary-stat.standard .stat-icon { color: var(--success); }
.summary-stat.caution .stat-icon { color: var(--warning); }
.summary-stat.avoid .stat-icon { color: var(--danger); }

.stat-number {
    display: block;
    font-size: 2rem;
    font-weight: 700;
    line-height: 1;
    margin-bottom: 0.25rem;
}

.summary-stat.standard .stat-number { color: var(--success); }
.summary-stat.caution .stat-number { color: var(--warning); }
.summary-stat.avoid .stat-number { color: var(--danger); }

.stat-label {
    display: block;
    font-size: 0.6875rem;
    color: var(--gray-600);
    text-transform: uppercase;
    letter-spacing: 0.025em;
    font-weight: 500;
}

.alert-drugs {
    margin-top: 1rem;
    padding-top: 1rem;
    border-top: 1px solid var(--gray-200);
}

.alert-drugs h4 {
    font-size: 0.875rem;
    color: var(--gray-700);
    margin-bottom: 0.5rem;
}

.alert-drugs ul {
    list-style: none;
    margin: 0;
    padding: 0;
}

.alert-drugs li {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    padding: 0.625rem 0.5rem;
    font-size: 0.875rem;
    border-bottom: 1px solid var(--gray-100);
    cursor: pointer;
    border-radius: var(--radius-sm);
    margin: 0 -0.5rem;
    transition: background 0.15s;
}

.alert-drugs li:hover {
    background: var(--gray-50);
}

.alert-drugs li:last-child {
    border-bottom: none;
}

.alert-drugs .drug-arrow {
    margin-left: auto;
    color: var(--gray-400);
    font-size: 0.875rem;
    transition: transform 0.15s, color 0.15s;
}

.alert-drugs li:hover .drug-arrow {
    transform: translateX(3px);
    color: var(--primary);
}

.alert-drugs .drug-name {
    font-weight: 500;
    color: var(--gray-800);
}

.alert-drugs .drug-action {
    font-size: 0.75rem;
    padding: 0.125rem 0.5rem;
    border-radius: 4px;
}

.alert-drugs .drug-action.caution {
    background: var(--warning-light);
    color: var(--warning);
}

.alert-drugs .drug-action.avoid {
    background: var(--danger-light);
    color: var(--danger);
}

/* Wallet Card Button */
.wallet-card-btn {
    display: block;
    width: 100%;
    margin-top: 1.25rem;
    padding: 0.875rem 1.5rem;
    background: linear-gradient(135deg, var(--primary) 0%, var(--primary-dark) 100%);
    color: white;
    border: none;
    border-radius: var(--radius-sm);
    font-size: 1rem;
    font-weight: 600;
    cursor: pointer;
    box-shadow: var(--shadow);
    transition: transform 0.15s, box-shadow 0.15s;
}

.wallet-card-btn:hover {
    transform: translateY(-2px);
    box-shadow: var(--shadow-lg);
}

/* Wallet Modal */
.wallet-modal-content {
    max-width: 400px;
    padding: 1.5rem;
}

.wallet-card-container {
    display: flex;
    justify-content: center;
    margin-bottom: 1rem;
}

.wallet-card {
    width: 100%;
    max-width: 340px;
    background: linear-gradient(145deg, #1e3a5f 0%, #0d1b2a 100%);
    border-radius: 16px;
    padding: 1.25rem;
    color: white;
    box-shadow: 0 10px 40px rgba(0, 0, 0, 0.3);
    font-size: 0.875rem;
}

.wallet-card-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: 1rem;
    padding-bottom: 0.75rem;
    border-bottom: 1px solid rgba(255, 255, 255, 0.2);
}

.wallet-logo {
    font-weight: 700;
    font-size: 1.125rem;
}

.wallet-title {
    font-size: 0.6875rem;
    text-transform: uppercase;
    letter-spacing: 0.05em;
    opacity: 0.8;
}

.wallet-card-body {
    min-height: 120px;
}

.wallet-section {
    margin-bottom: 1rem;
}

.wallet-label {
    font-size: 0.6875rem;
    text-transform: uppercase;
    letter-spacing: 0.05em;
    opacity: 0.7;
    margin-bottom: 0.375rem;
}

.wallet-genes {
    display: flex;
    flex-wrap: wrap;
    gap: 0.375rem;
}

.wallet-gene-tag {
    background: rgba(255, 255, 255, 0.15);
    padding: 0.25rem 0.5rem;
    border-radius: 4px;
    font-size: 0.75rem;
    font-family: monospace;
}

.wallet-gene-tag.warning {
    background: rgba(202, 138, 4, 0.3);
    border: 1px solid rgba(202, 138, 4, 0.5);
}

.wallet-gene-tag.danger {
    background: rgba(220, 38, 38, 0.3);
    border: 1px solid rgba(220, 38, 38, 0.5);
}

.wallet-avoid-section {
    background: rgba(220, 38, 38, 0.15);
    margin: 0 -1.25rem;
    padding: 0.75rem 1.25rem;
    border-top: 1px solid rgba(220, 38, 38, 0.3);
    border-bottom: 1px solid rgba(220, 38, 38, 0.3);
}

.wallet-avoid-list {
    display: flex;
    flex-wrap: wrap;
    gap: 0.375rem;
}

.wallet-avoid-drug {
    background: rgba(255, 255, 255, 0.1);
    padding: 0.1875rem 0.5rem;
    border-radius: 4px;
    font-size: 0.75rem;
}

.wallet-card-footer {
    margin-top: 1rem;
    padding-top: 0.75rem;
    border-top: 1px solid rgba(255, 255, 255, 0.2);
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.wallet-disclaimer {
    font-size: 0.625rem;
    opacity: 0.7;
    max-width: 60%;
}

.wallet-url {
    font-size: 0.6875rem;
    opacity: 0.5;
}

.wallet-actions {
    display: flex;
    gap: 0.75rem;
}

.wallet-action-btn {
    flex: 1;
    padding: 0.75rem 1rem;
    background: var(--gray-100);
    border: 1px solid var(--gray-300);
    border-radius: var(--radius-sm);
    font-size: 0.875rem;
    font-weight: 500;
    cursor: pointer;
    transition: background 0.15s;
}

.wallet-action-btn:hover {
    background: var(--gray-200);
}

/* Print styles for wallet card */
@media print {
    body * {
        visibility: hidden;
    }
    .wallet-card, .wallet-card * {
        visibility: visible;
    }
    .wallet-card {
        position: absolute;
        left: 50%;
        top: 50%;
        transform: translate(-50%, -50%);
        width: 3.375in;
        height: 2.125in;
        box-shadow: none;
        -webkit-print-color-adjust: exact;
        print-color-adjust: exact;
    }
}

/* Drug Search */
.drug-search {
    position: relative;
    margin-bottom: 1rem;
}

.drug-search input {
    width: 100%;
    padding: 0.875rem 1rem;
    border: 2px solid var(--gray-200);
    border-radius: var(--radius-sm);
    font-size: 1rem;
    transition: border-color 0.2s ease;
}

.drug-search input:focus {
    outline: none;
    border-color: var(--primary);
}

.suggestions {
    position: absolute;
    top: 100%;
    left: 0;
    right: 0;
    background: white;
    border: 1px solid var(--gray-200);
    border-radius: var(--radius-sm);
    box-shadow: var(--shadow-lg);
    max-height: 200px;
    overflow-y: auto;
    z-index: 10;
}

.suggestion-item {
    padding: 0.75rem 1rem;
    cursor: pointer;
    border-bottom: 1px solid var(--gray-100);
}

.suggestion-item:hover {
    background: var(--gray-50);
}

.suggestion-item:last-child {
    border-bottom: none;
}

/* Common Drugs */
.common-drugs {
    margin-bottom: 1.5rem;
}

.common-drugs p {
    font-size: 0.875rem;
    color: var(--gray-500);
    margin-bottom: 0.5rem;
}

.drug-chips {
    display: flex;
    flex-wrap: wrap;
    gap: 0.5rem;
}

.drug-chip {
    background: white;
    border: 1px solid var(--gray-300);
    border-radius: 20px;
    padding: 0.375rem 0.875rem;
    font-size: 0.875rem;
    cursor: pointer;
    transition: all 0.2s ease;
}

.drug-chip:hover {
    background: var(--primary);
    color: white;
    border-color: var(--primary);
}

/* Drug Result */
.drug-result {
    background: white;
    border-radius: var(--radius);
    box-shadow: var(--shadow);
    overflow: hidden;
}

.drug-result-header {
    padding: 1rem;
    border-bottom: 1px solid var(--gray-200);
}

.drug-result-header h3 {
    font-size: 1.125rem;
    color: var(--gray-800);
    text-transform: capitalize;
}

.drug-result-header .drug-class {
    font-size: 0.8125rem;
    color: var(--gray-500);
}

.drug-result-body {
    padding: 1rem;
}

.result-section {
    margin-bottom: 1rem;
}

.result-section:last-child {
    margin-bottom: 0;
}

.result-section h4 {
    font-size: 0.8125rem;
    text-transform: uppercase;
    letter-spacing: 0.5px;
    color: var(--gray-500);
    margin-bottom: 0.5rem;
}

.recommendation-box {
    padding: 1rem;
    border-radius: var(--radius-sm);
    margin-bottom: 1rem;
}

.recommendation-box.standard {
    background: var(--success-light);
    border: 1px solid var(--success);
}

.recommendation-box.caution {
    background: var(--warning-light);
    border: 1px solid var(--warning);
}

.recommendation-box.avoid {
    background: var(--danger-light);
    border: 1px solid var(--danger);
}

.recommendation-box h4 {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    margin-bottom: 0.5rem;
}

.recommendation-box.standard h4 { color: var(--success); }
.recommendation-box.caution h4 { color: var(--warning); }
.recommendation-box.avoid h4 { color: var(--danger); }

.recommendation-box p {
    font-size: 0.9375rem;
    color: var(--gray-700);
}

.fda-label {
    background: var(--gray-100);
    padding: 0.75rem;
    border-radius: var(--radius-sm);
    font-size: 0.875rem;
    color: var(--gray-600);
    font-style: italic;
}

.source-link {
    display: inline-block;
    margin-top: 0.75rem;
    font-size: 0.8125rem;
    color: var(--primary);
    text-decoration: none;
}

.source-link:hover {
    text-decoration: underline;
}

/* Modal */
.modal {
    position: fixed;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: rgba(0, 0, 0, 0.5);
    display: flex;
    align-items: center;
    justify-content: center;
    padding: 1rem;
    z-index: 100;
}

.modal.hidden {
    display: none;
}

.modal-content {
    background: white;
    border-radius: var(--radius);
    max-width: 500px;
    width: 100%;
    max-height: 80vh;
    overflow-y: auto;
    position: relative;
}

.modal-close {
    position: absolute;
    top: 0.5rem;
    right: 0.75rem;
    background: none;
    border: none;
    font-size: 1.5rem;
    color: var(--gray-400);
    cursor: pointer;
    padding: 0.25rem;
    line-height: 1;
}

.modal-close:hover {
    color: var(--gray-600);
}

#modal-body {
    padding: 1.5rem;
}

/* Footer */
.app-footer {
    background: var(--gray-800);
    color: var(--gray-300);
    padding: 1.25rem 1rem;
    font-size: 0.8125rem;
}

.disclaimer {
    background: var(--gray-700);
    padding: 0.75rem;
    border-radius: var(--radius-sm);
    margin-bottom: 1rem;
}

.disclaimer strong {
    color: var(--warning);
}

.footer-info {
    text-align: center;
}

.footer-info a {
    color: var(--primary-light);
    text-decoration: none;
}

.footer-info a:hover {
    text-decoration: underline;
}

.privacy {
    margin-top: 0.5rem;
    color: var(--success);
}

/* Utility Classes */
.hidden {
    display: none !important;
}

/* Back Button - Upload Different File */
.back-btn {
    display: inline-flex;
    align-items: center;
    gap: 0.375rem;
    background: var(--primary);
    border: none;
    color: white;
    font-size: 0.9375rem;
    font-weight: 500;
    cursor: pointer;
    margin-bottom: 1rem;
    padding: 0.625rem 1.25rem;
    border-radius: var(--radius-sm);
    box-shadow: var(--shadow);
    transition: background 0.2s, transform 0.1s;
}

.back-btn:hover {
    background: var(--primary-dark);
    transform: translateY(-1px);
}

.back-btn:active {
    transform: translateY(0);
}

/* Status File */
.file-status {
    background: white;
    border: 1px solid var(--success);
    border-radius: var(--radius-sm);
    padding: 0.75rem 1rem;
    margin-top: 1rem;
    display: flex;
    align-items: center;
    justify-content: space-between;
}

.file-status .file-name {
    color: var(--gray-700);
    font-size: 0.875rem;
}

.file-status .file-check {
    color: var(--success);
}

/* Responsive Adjustments */
@media (min-width: 480px) {
    .app-header {
        padding: 2rem 1.5rem;
    }

    .logo-text {
        font-size: 2rem;
    }

    .step-content {
        padding: 1.5rem;
    }

    .upload-zone {
        padding: 3rem 2rem;
    }
}

@media (min-width: 768px) {
    body {
        padding: 2rem 1rem;
    }

    .app-container {
        border-radius: var(--radius);
        min-height: auto;
    }
}